How culture as issue can influence or impact in an organization?

This is really interesting and matters to many companies for different sizes; and it is becoming more important when the world is smaller.

As how it has influence in the organization, it is much easier to say and to notice. How it has impact in an organization? Which kind of impact it is?-- For this, you might only be able to notice and tell not when it starts but at a much later stage.

The impacts include: start the sub-group among employees;  inefficient communication and work; challenge for the management...

For a healthy organization, it can cure itself by facing the issue and leading to an open but objective work environment; and it might eventually turn a negative to a positive fact for developing the company culture. But it requires the determination and strength of the management.

But how the impact starts? If we know this, we can already stop it there. We might only see the different views, standing points, actions as a daily phoneme, and these are not sufficient enough to alert us.